Efficacy of monensin against coccidiosis in lambs. 1978

L R McDougald, and W J Dunn

Lambs fed monensin mixed in a complete fattening ration at concentrations of 5, 10, or 20 ppm were protected against death, impaired body weight gain, and diarrhea due to infections of Eimeria ninakohlyakimovae and E ahsata. Monensin given at the concentration of 10 ppm reduced oocyst passage and, at the concentration of 20 ppm, almost completely controlled oocyst passage. Protection was afforded by monensin given at the concentration of 5 ppm, although oocyst passage was excessive and body weight gains were suboptimal. Infected control lambs were severely affected, with mortality rate of 30% to 50% on days 14 to 18 and oocyst passage averaging 286,000,000 oocyst/lamb, Oocyst production peaks on days 12 to 15 and 21 to 27 correlated with the appearance of oocysts of E ninakohlyakimovae and E ahsata, respectively. Body weight gains and feed consumption of lambs fed monensin at the concentration of 10 or 20 ppm indicated that the drug was well tolerated at these dose levels and this route of administration. The compound was efficacious in Dorset and Suffolk X Hampshire lambs, and caused no problems when fed to pregnant ewes.

UI MeSH Term Description Entries
D007422 Intestines The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE. Intestine
D008985 Monensin An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies. Coban,Monensin Monosodium Salt,Monensin Sodium,Monensin-A-Sodium Complex,Rumensin,Monensin A Sodium Complex
D003048 Coccidiosis Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA. Besnoitiasis,Besnoitiosis,Besnoitiases,Besnoitioses,Coccidioses
D005663 Furans Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran. Tetrahydrofurans
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D012757 Sheep Diseases Diseases of domestic and mountain sheep of the genus Ovis. Ovine Diseases,Disease, Ovine,Disease, Sheep,Diseases, Ovine,Diseases, Sheep,Ovine Disease,Sheep Disease

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