Immunisation of lambs against coccidiosis. 1993

J Catchpole, and C C Norton, and M W Gregory
Central Veterinary Laboratory, Addlestone, Surrey.

Two groups of twin lambs, kept with their dams at pasture, were given 10,000 oocysts of Eimeria crandallis and 10,000 oocysts of E ovinoidalis either at birth only, or on four occasions at weekly intervals. A further group received 1000 oocysts of each species three times a week in a 'trickle infection' from birth to 21 days of age. All these lambs, together with a susceptible control group were challenged with 100,000 oocysts of each species at 28 days of age. A fifth group received no inoculations throughout. Bodyweight, faecal consistency and oocyst output were monitored up to nine weeks of age. There was no clinical response to any of the immunising inoculations and no change in the faecal consistency, but the group infected at birth grew significantly faster than the uninfected controls. The pattern of oocyst output showed that only E crandallis developed fully in the newborn animal, but both species multiplied in seven-day-old lambs. The challenge infection produced 80 per cent mortality in the susceptible control group and 20 per cent mortality in the group which had received only one immunising dose at birth. The other immunised groups were well protected and gained more weight than the unchallenged controls. At nine weeks of age, the weight gain of the lambs which had received the 'trickle infection' was significantly higher than that of all the other groups.

UI MeSH Term Description Entries
D007114 Immunization Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow). Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D008297 Male Males
D003048 Coccidiosis Protozoan infection found in animals and man. It is caused by several different genera of COCCIDIA. Besnoitiasis,Besnoitiosis,Besnoitiases,Besnoitioses,Coccidioses
D004539 Eimeria A genus of protozoan parasites of the subclass COCCIDIA. Various species are parasitic in the epithelial cells of the liver and intestines of man and other animals. Eimerias
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D012757 Sheep Diseases Diseases of domestic and mountain sheep of the genus Ovis. Ovine Diseases,Disease, Ovine,Disease, Sheep,Diseases, Ovine,Diseases, Sheep,Ovine Disease,Sheep Disease
D015430 Weight Gain Increase in BODY WEIGHT over existing weight. Gain, Weight,Gains, Weight,Weight Gains

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