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1. The glycosphingolipid compositions of the thymus and bursa of Fabricius of young male chickens were compared. The two tissues were found to contain complex mixtures of both neutral glycosphingolipids and gangliosides. Both tissues contained mono-, di-, tri-, tetra- and penta-glycosylceramides; the pentaglycosylceramide displayed a reaction of identity with authentic Forssman antigen when tested against a specific anti-(Forssman antigen) serum. The ganglioside G(m3) containing N-acetylneuraminic acid was the principle ganglioside of both tissues. 2. The thymus contained appreciable amounts of the simple ganglioside N-acetylneuraminylgalactosylceramide, a compound not found in the bursa. The ganglioside G(d3) (disialohaematoside) was detected in both tissues. 3. Rat and human thymus, like sheep thymus (Narasimhan, Hay, Greaves & Murray (1976) Biochim, Biophys. Acta 431, 578-591), both contained a tetraglycosylceramide species as their most complex neutral glycosphingolipid and possessed little or no Forssman antigen. They also contained a complex mixture of gangliosides. 4. The possible significance of these results is briefly discussed.
R Narasimhan, and
R K Murray
March 1973,
Comparative biochemistry and physiology. A, Comparative physiology,
R Narasimhan, and
R K Murray
August 1979,
Zentralblatt fur Veterinarmedizin. Reihe A,
R Narasimhan, and
R K Murray
February 1982,
Thymus,
R Narasimhan, and
R K Murray
June 1998,
Molecular and cellular endocrinology,
R Narasimhan, and
R K Murray
November 1971,
Poultry science,
R Narasimhan, and
R K Murray
October 1967,
The American journal of pathology,
R Narasimhan, and
R K Murray
January 1967,
Folia biologica,
R Narasimhan, and
R K Murray
January 1996,
Advances in experimental medicine and biology,
R Narasimhan, and
R K Murray
May 1995,
The Anatomical record,
R Narasimhan, and
R K Murray
January 1975,
International archives of allergy and applied immunology,
