Progesterone receptor in chicken bursa of Fabricius and thymus: evidence for expression in B-lymphocytes. 1998

S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
Department of Anatomy and Graduate School of Steroid Research, Medical School, University of Tampere, Finland. spasanen@csc.fi

In the present work constitutive progesterone receptor (PR) expression in the chicken bursa of Fabricius was detected in the stromal, smooth muscle and follicular medullary cells and smooth muscle cells of blood vessels. PR expression was increased during sexual maturation and after estrogen treatment. Bursal medullary PR-positive cells were further characterized to be B-lymphocytes by flow cytometric analysis. In addition, estrogen induced expression of PR in the bursal FAE-cells (follicle-associated epithelial cells). In the thymus PR was expressed constitutively in the connective tissue cells of the capsule and interfollicular septa, in a few medullary cells and in vascular smooth muscle. The PR-positive medullary cells consisted of epithelial cells, large polygonal cells resembling macrophages and plasma cells. T-lymphocytes were PR-negative. Estrogen up-regulated PR expression in the thymus. Immunoblotting studies revealed that both isoforms of PR, i.e. PR-A and PR-B, were expressed in the bursa of Fabricius and thymus with PR-B dominance. These results suggest that the chicken primary lymphoid organs bursa and thymus are under regulation of estrogen and progesterone. Expression of PR in B-lymphocytes, macrophages and plasma cells in the chicken is documented for the first time and suggests evidence for direct action of progesterone on immune responses.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D009130 Muscle, Smooth Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed) Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D009131 Muscle, Smooth, Vascular The nonstriated involuntary muscle tissue of blood vessels. Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D010950 Plasma Cells Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20) Plasmacytes,Cell, Plasma,Cells, Plasma,Plasma Cell,Plasmacyte
D011980 Receptors, Progesterone Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives. Progesterone Receptors,Progestin Receptor,Progestin Receptors,Receptor, Progesterone,Receptors, Progestin,Progesterone Receptor,Receptor, Progestin
D002060 Bursa of Fabricius An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation. Fabricius Bursa
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D004847 Epithelial Cells Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot

Related Publications

S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
March 1973, Comparative biochemistry and physiology. A, Comparative physiology,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
January 2001, Developmental and comparative immunology,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
November 1975, Annals of allergy,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
May 1989, European journal of immunology,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
June 1983, European journal of immunology,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
May 1987, Journal of immunology (Baltimore, Md. : 1950),
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
January 1987, Progress in clinical and biological research,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
August 1979, Zentralblatt fur Veterinarmedizin. Reihe A,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
April 1995, Endocrinology,
S Pasanen, and T Ylikomi, and E Palojoki, and H Syvälä, and M Pelto-Huikko, and P Tuohimaa
August 1978, The Biochemical journal,
Copied contents to your clipboard!