-transparent.png){kind=logo}
Complement-mediated cytolysis has been used to remove T-lymphocytes from suspensions of human peripheral blood and bone marrow. Selective T-cell removal was investigated by three monoclonal antibodies. OKT3, MBG6 and OKT11A. All three removed greater than 90% of T-cells but combinations were necessary to kill greater than 99% of T-cells in vitro. The macrophage-granulocyte and erythroid colony forming cells of the bone marrow were spared. The method can be applied on bulk BM samples during clinical BM transplantation and will be useful to establish whether the virtually complete removal of T-lymphocytes totally prevents transplant associated graft-versus-host disease in man.
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
October 1987,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
February 1985,
Cancer research,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
March 1984,
Presse medicale (Paris, France : 1983),
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
March 1983,
Cancer research,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
August 1991,
Chinese medical journal,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
May 1985,
Blood,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
September 1982,
Blood,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
January 1990,
Progress in clinical and biological research,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
January 1987,
Haematology and blood transfusion,
S Granger, and
G Janossy, and
G Francis, and
H Blacklock, and
L W Poulter, and
A V Hoffbrand
August 1984,
Journal of biological response modifiers,
