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24,25-Dihydroxycholecalciferol, an active D3 vitamin metabolite, at a dose of 1.25 microgram/day/animal prevents bone osteoporotic changes, effectively stimulating the diaphyseal and epiphyseal mineralization, and corrects hypocalcemia of hypokinetic rats. 24,25(OH)2D3 at the above dose does not increase nephrocalcinosis or does not produce the toxic effect as measured by body mass variations.
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