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To study the effect of physiological increments in plasma secretin concentrations on basal and glucose-stimulated insulin release, bolus iv glucose injections (5 g) were given to normal weight volunteers (less than 108% ideal BW) before, during, and 30 min after a secretin infusion at a rate of 0.125 U/kg.h, raising mean plasma immunoreactive secretin to 35.5 +/- 8.3 pg/ml. Acute insulin responses to glucose were unaffected during or after the secretin infusion. Furthermore, when plasma glucose was elevated to postprandial levels (128--165 mg/dl), a similar secretin infusion also failed to alter acute insulin responses. In addition, no changes in basal glucose or insulin levels were found when endogenous secretin concentrations were increased by intraduodenal acid infusion. Thus, increases in plasma secretin to concentrations seen in the postprandial state fail to alter acute insulin secretion. It is unlikely that secretin plays any role in the intestinal stimulation of insulin secretion.
R G Brodows, and
W Y Chey
September 1984,
Regulatory peptides,
R G Brodows, and
W Y Chey
September 1987,
The Journal of clinical endocrinology and metabolism,
R G Brodows, and
W Y Chey
April 2000,
Neuroendocrinology,
R G Brodows, and
W Y Chey
September 2021,
Proceedings of the National Academy of Sciences of the United States of America,
R G Brodows, and
W Y Chey
September 2007,
Leukemia & lymphoma,
R G Brodows, and
W Y Chey
January 1987,
Progress in medicinal chemistry,
R G Brodows, and
W Y Chey
July 1972,
The Journal of clinical endocrinology and metabolism,
R G Brodows, and
W Y Chey
April 1988,
The American journal of physiology,
R G Brodows, and
W Y Chey
August 2013,
Pancreas,
R G Brodows, and
W Y Chey
June 1985,
The American journal of physiology,
