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In Sprague-Dawley rats with unilateral renal artery stenosis and an intact contralateral kidney, administration of a low-sodium diet did not prevent the development of hypertension. Despite an elevated blood pressure, hyponatremia, marked activation of the renin-angiotensin system, and increased hematocrit values, only 10% of the rats showed lesions of malignant hypertension. Systolic blood pressures of one- and two-kidney sham-operated rats fed a low-sodium diet were significantly higher than that of normotensive controls fed a normal diet. Uninephrectomy did not reduce plasma renin activity. The low-sodium diet increased plasma renin activity to about the same level in one- and two-kidney normotensive rats. However, the increase in plasma renin activity elicited by dietary sodium restriction was markedly less in one-kidney Goldblatt hypertension. Systolic blood pressure reached similar levels in one- and two-kidney Goldblatt hypertensive rats fed a low-sodium diet. These data indicate that a decrease in sodium intake does not prevent the development of two-kidney Goldblatt hypertension.
H Muñoz-Ramírez, and
R E Chatelain, and
F M Bumpus, and
P A Khairallah
September 1982,
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H Muñoz-Ramírez, and
R E Chatelain, and
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P A Khairallah
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H Muñoz-Ramírez, and
R E Chatelain, and
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P A Khairallah
April 1992,
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H Muñoz-Ramírez, and
R E Chatelain, and
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H Muñoz-Ramírez, and
R E Chatelain, and
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H Muñoz-Ramírez, and
R E Chatelain, and
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H Muñoz-Ramírez, and
R E Chatelain, and
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H Muñoz-Ramírez, and
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H Muñoz-Ramírez, and
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P A Khairallah
August 1979,
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H Muñoz-Ramírez, and
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P A Khairallah
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