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Synthetic neurotensin was infused into five healthy subjects at a mean dose of 2.3 pmol/kg . min for 30 min, producing a rise in plasma neurotensin concentrations, measured by RIA of 104 +/- 10 (mean +/- SEM) pmol/liter. The mean disappearance half-time on stopping the infusion was 3.8 +/- 0.2 min. The MCR was 16 +/- 1 ml/kg . min, and the apparent space of distribution was 88 +/- 6 ml/kg. During the neurotensin infusions, plasma pancreatic polypeptide rose by 145 +/- 54 pmol/liter. In contrast to results in experimental animals, there was no significant change in the pulse or blood pressure of the subjects or any significant change in blood glucose or plasma concentrations of insulin, glucagon, gastric inhibitory peptide, gastrin, motilin, or vasoactive intestinal peptide. Similarly, there was no change in plasma concentrations of TSH, GH, PRL, LH, and FSH.
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
May 1984,
Clinical endocrinology,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
January 1980,
British journal of clinical pharmacology,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
February 1989,
The Journal of clinical endocrinology and metabolism,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
January 1984,
Postepy higieny i medycyny doswiadczalnej,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
November 1980,
Acta physiologica Scandinavica,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
March 1985,
Regulatory peptides,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
October 1988,
Drug and alcohol dependence,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
July 1987,
Regulatory peptides,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
August 1986,
Regulatory peptides,
A M Blackburn, and
D R Fletcher, and
T E Adrian, and
S R Bloom
April 1981,
Scandinavian journal of gastroenterology,
