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1. Isolated rat kidneys were perfused with a modified Krebs-Henseleit medium at constant pressure. 2. When prostaglandin F2 alpha (PGF2 alpha) was infused into these kidneys at 0.1 mumol/l (final concentration) PGF2 alpha-derived prostaglandin E2 (PGE2) could be identified by high-performance liquid chromatography and combined gas chromatography-mass spectrometry. 3. The extent of this conversion of PGF2 alpha into PGE2 during passage through the kidney is dependent on the salt history of the rats from which the kidneys were taken for perfusion: kidneys from rats kept on normal diet converted 10%, those from rats on a low sodium diet 5% and those from rats kept on a high sodium diet 11%. 4. These differences in conversion can account for the different increases in renin release after PGF2 alpha infusion in these groups.
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
January 1976,
Clinical and experimental pharmacology & physiology,
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
August 1976,
Journal of neurochemistry,
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
August 1987,
European journal of pharmacology,
U Schwertschlag, and
H W Seyberth, and
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R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
October 1987,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
U Schwertschlag, and
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H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
June 1992,
Journal of applied physiology (Bethesda, Md. : 1985),
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
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E Hackenthal
October 1982,
European journal of pharmacology,
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
June 1982,
Naunyn-Schmiedeberg's archives of pharmacology,
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
May 2003,
European journal of pharmacology,
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
July 1983,
Kidney international,
U Schwertschlag, and
H W Seyberth, and
H Müller, and
R Grunewald, and
T Erlenmaier, and
H G Rohs, and
E Hackenthal
January 1993,
Journal of applied physiology (Bethesda, Md. : 1985),
