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The in vitro function of granulocytes collected by filtration leukapheresis after premedication of donors with dexamethasone was found to be normal. In vivo studies were performed in a 21-year-old woman who was transplanted with allogeneic bone marrow for severe aplastic anaemia. The patient received granulocyte transfusions for treatment of septicaemia during the transplantation period. On 11 consecutive days an average dose of 7.2 X 10(10) granulocytes/transplantation, the patient died from cardiac failure. Transfused granulocytes were found ante mortem in a pericardial effusion and post mortem in lungs, kidneys, liver and spleen. The data indicate that filter collected granulocytes function normally in the recipient and are clinically effective.
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
October 1997,
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
May 1978,
Scandinavian journal of haematology,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
January 1978,
Transfusion,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
January 1997,
Scandinavian cardiovascular journal : SCJ,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
February 1995,
Bioseparation,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
January 1982,
Progress in clinical and biological research,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
April 1974,
Japanese journal of medical science & biology,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
November 2001,
Transfusion,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
January 1995,
Journal of vascular and interventional radiology : JVIR,
R Arnold, and
H Pflieger, and
M Wiesneth, and
S Bhaduri, and
B Bültmann, and
H Heimpel
January 1984,
Vox sanguinis,
