[Osteogenetic induction (critical comments to the concept "bone graft") (author's transl)]. 1980

R de Souza-Ramos

The author makes an attempt to prove the following facts on the basis of his histological studies: 1. The mechanical process of cutting out small bone fragments from the outer cortex of the long bones of fragments from the outer cortex of the long bones of living humans results in an immediate devitalisation or emptying of the lacunae. 2. In almost 74% of the cases, there is an emptying of the lacunae or absence of the mature osteocytes, as well as degeneration--albeit to a varying degree--in almost 95% of the remaining osteocytes. 3. These facts, i.e. immediate devitalisation of these small fragments of living bones, prompted the author to question the expression "bone graft", even with free or floating bone fragments taken from the same patient, i.e. also with the socalled autogenic or autologus bone grafts. 4. Transplanting or grafting a living bone fragment from the donor area to a recipient area will stimulate the recipient area to form new bones. In this manner, it is possible to achieve osteogenetic induction, and expression which respresents the course of facts with biological accuracy. 5. The mature osteocyte does not participate as a living cell in the osteogenetic process of rehabilitation, does not multiply, and dies. 6. The new bone is shaped by the recipient and not by the grafted bone of the donor.

UI MeSH Term Description Entries
D010011 Osteocytes Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. Osteocyte
D010012 Osteogenesis The process of bone formation. Histogenesis of bone including ossification. Bone Formation,Ossification, Physiologic,Endochondral Ossification,Ossification,Ossification, Physiological,Osteoclastogenesis,Physiologic Ossification,Endochondral Ossifications,Ossification, Endochondral,Ossifications,Ossifications, Endochondral,Osteoclastogeneses,Physiological Ossification
D001842 Bone and Bones A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX. Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D001846 Bone Development The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS. Bone Growth
D002146 Bony Callus The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing. Callus,Callus, Bony
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014182 Transplantation, Autologous Transplantation of an individual's own tissue from one site to another site. Autografting,Autologous Transplantation,Autotransplantation,Autograftings,Autologous Transplantations,Autotransplantations,Transplantations, Autologous
D014184 Transplantation, Homologous Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals. Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D016025 Bone Transplantation The grafting of bone from a donor site to a recipient site. Grafting, Bone,Transplantation, Bone,Bone Grafting
D050723 Fractures, Bone Breaks in bones. Bone Fractures,Broken Bones,Spiral Fractures,Torsion Fractures,Bone Fracture,Bone, Broken,Bones, Broken,Broken Bone,Fracture, Bone,Fracture, Spiral,Fracture, Torsion,Fractures, Spiral,Fractures, Torsion,Spiral Fracture,Torsion Fracture

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