Biomaterial Database

[Critical comments on the calculation of receptor analyses (author's transl)]. 1982

E Kuss

The main literature concerning the processing of binding data is reviewed. Practical conclusions for the measurement of association constants and binding site concentrations are considered from the standpoint of basic binding theory in connection with basic information theory. The theoretical minimum errors in the association constant and the binding site concentration are discussed as a function of the saturation fraction of the most dilute component. Various plotting forms and the error arising from various rearrangements of the basic binding equation are discussed. For fitting procedure several heuristic models are mentioned and it is recommended to start from the most general Adair function. The necessity of well defined criteria for quality of fit in computer programming for iterative curve fitting procedures is emphasized. The most frequent, however avoidable, errors are mentioned.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D011955	Receptors, Drug	Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.	Drug Receptors,Drug Receptor,Receptor, Drug
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia