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Urine from coke plant workers, collected before and after work, were tested for the content of mutagenic substances in the Salmonella test system. Urine extracts from exposed smokers showed mutagenic activity, whereas urine from exposed nonsmokers did not. The mutagenicity of exposed smoker's urine was not significantly different from that of urine from nonexposed smokers. Mutagenicity of smokers' urine was only evident in the presence of a rat liver metabolic activation system. The addition of beta-glucuronidase did not enhance the mutagenic effect. The facts that coke plant workers are exposed to very high levels of polycyclic aromatic hydrocarbons (PAH) and that there is no observed enhanced mutagenicity of their urine indicate that the mutagenicity observed with urine from smokers is not due to conventional PAH.
M Møller, and
E Dybing
June 1989,
Mutation research,
M Møller, and
E Dybing
January 1992,
Polish journal of occupational medicine and environmental health,
M Møller, and
E Dybing
March 1987,
Carcinogenesis,
M Møller, and
E Dybing
October 1989,
Mutation research,
M Møller, and
E Dybing
January 1984,
IARC scientific publications,
M Møller, and
E Dybing
January 1979,
Drug and chemical toxicology,
M Møller, and
E Dybing
January 1988,
Journal of toxicology and environmental health,
M Møller, and
E Dybing
July 1985,
British journal of industrial medicine,
M Møller, and
E Dybing
January 1990,
Medycyna pracy,
M Møller, and
E Dybing
January 1991,
Mutation research,
