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Three patients with disseminated, relapsed Ewing's sarcoma refractory to conventional chemotherapy were treated with high-dose melphalan, cyclophosphamide pretreatment, and bone marrow autotransplantation. Two patients achieved complete remission and one achieved partial remission. The two patients who achieved complete remission remain disease-free at 12 and 13 months. High-dose melphalan is effective when conventional approaches have failed.
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