Biomaterial Database

Kinetics of antigen-sensitive cells in the lymphoid organs of rats during allotransplantation reaction. 1981

E Koníková, and M Klobusická

The kinetics of antigen-sensitive cells in the peripheral blood, spleens, regional lymph nodes, and thymuses of rats was investigated at different time intervals after immunization with allogeneic lymph node cells or after immunization with allogeneic skin or tumour grafts. The lytic effect of the immunizing antigen in vitro was estimated by the percentage of surviving cells after 24 h incubation with the specific antigen prepared from the lymph nodes of graft donors. The percentage of active lymphocytes in individual lymphoid organs of rats immunized with allogenic lymphocyte suspensions was determined by the nucleolar test. Regional lymph node enlargement was evaluated by determining lymph node relative weights and enlargement indices. An immunologically specific enlargement of the regional lymph nodes, increased numbers of ASC and increased percentage of active lymphocytes were seen as early as 24 h after immunization with allogeneic lymph node cells. At this time, the number of ASC in the peripheral blood was reduced and the percentage of active lymphocytes was low. After immunization with allogeneic skin and tumour grafts, ASC were detected first in the peripheral blood, then in the regional lymph nodes as late as 8 days after immunization, and after 10 days in the spleens.

UI	MeSH Term	Description	Entries
D007114	Immunization	Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).	Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008297	Male		Males
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D003602	Cytotoxicity, Immunologic	The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.	Tumoricidal Activity, Immunologic,Immunologic Cytotoxicity,Immunologic Tumoricidal Activities,Immunologic Tumoricidal Activity,Tumoricidal Activities, Immunologic
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000941	Antigens	Substances that are recognized by the immune system and induce an immune reaction.	Antigen