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We report the use of the orally active converting enzyme inhibitor Captopril in hypertensive patients with mild chronic renal failure. Twenty eight patients were followed for a period of six months. Eleven patients required the addition of furosemide. Mean arterial pressure (MAP) decreased in all but two at six months (MAP: 102 +/- 0.8 vs 133 +/- 2.2mmHg, p less than 0.001). Untoward effects were frequent: the commonest reactions are loss of taste (four patients), skin rashes (11 patients), proteinuria (2 patients), tachycardia (2 cases). These side effects disappeared after reduction of dose (10 cases) or withdrawal (8 cases). Patients on 300mg daily or less were free of any untoward effect. In summary (i) Captopril alone or in combination with furosemide has an antihypertensive effect in patients with chronic renal failure and hypertension; (ii) side effects seem to be dose dependant and a reduced dosage should be used in these patients.
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
January 1986,
Clinical and experimental hypertension. Part A, Theory and practice,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
January 1986,
Postgraduate medical journal,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
June 1982,
Archives des maladies du coeur et des vaisseaux,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
January 1989,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
February 1994,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
January 1986,
Clinical and experimental hypertension. Part A, Theory and practice,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
April 1985,
Deutsche medizinische Wochenschrift (1946),
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
May 1981,
Journal of the Royal Society of Medicine,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
March 1987,
Annals of internal medicine,
J P Gassia, and
D Durand, and
H Ton That, and
F Degroc, and
J M Suc
May 1984,
The American journal of cardiology,
