-transparent.png){kind=logo}
The aim of this prospective study was to determine the ability of the captopril renogram to reveal the presence of angiotensin II-dependent renovascular disorder in hypertensive patients with chronic renal failure and to assess the possibility of predicting beneficial effect of angiotensin-converting enzyme (ACE) inhibitors on renal function. METHODS Forty-one patients were evaluated. Baseline renal scintigraphy was performed with 80 MBq of 99mTc-mercaptoacetyltriglycine (MAG3) injected intravenously. Scintigraphy was repeated within a week with 25 mg of oral captopril given 60 min prior to the test. Using the measurements outlined by the Working Party on Diagnostic Criteria of Renovascular Hypertension with Captopril Renography, the patients were categorized into high (7 patients), indeterminate (19 patients) and low (15 patients) probability for renal artery stenosis (RAS). RESULTS In five of the seven patients with high probability, the presence of RAS was confirmed angiographically and corrective surgical procedure performed in two. In patients with GFR of 10 ml/min/1.73 m2 and/or split renal function of 10% or less, all qualitative and semiquantitative scintigraphic parameters were nonspecific. Mean parenchymal transit time of tracer was a useful parameter to predict the beneficial effect of ACE inhibition therapy in 23 patients (14 low and 9 indeterminate probability of RAS). CONCLUSIONS In hypertensive patients with renal failure, captopril renal scintigraphy can be utilized to identify the presence of angiotensin II-dependent renal dysfunction and possibly help to predict the beneficial effect of ACE inhibitor therapy.
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
May 1981,
Journal of the Royal Society of Medicine,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
March 1999,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
May 1997,
American family physician,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
April 1995,
Kaku igaku. The Japanese journal of nuclear medicine,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
January 1986,
Clinical and experimental hypertension. Part A, Theory and practice,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
January 1986,
Postgraduate medical journal,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
January 1980,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
July 1993,
Revista medica de Chile,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
January 1992,
Terapevticheskii arkhiv,
I E Datseris, and
J B Bomanji, and
E A Brown, and
K S Nijran, and
A K Padhy, and
Q H Siraj, and
K E Britton
January 1988,
Biology of the neonate,
