Biomaterial Database

Genetic evidence for a second asparaginase in Aspergillus nidulans. 1980

H N Arst, and C R Bailey

The apnA1 mutation strongly reduces L-asparagine utilization in Aspergillus nidulans. The ahrA1 mutation, leading to loss of an L-asparaginase (Drainas et al., 1977), eliminates residual L-asparagine utilization in double mutant strains also carrying apnA1. This additivity suggests that A. nidulans, like Saccharomyces cerevisiae (Jones, 1977; Dunlop et al., 1978), has two L-asparaginases specified by apnA and Ahr A, respectively, apnA has been mapped to a position on the left arm of linkage group II, in the sequence adH--acrA--apnA--wA--methA--palcA--(centromere).

UI	MeSH Term	Description	Entries
D009154	Mutation	Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.	Mutations
D010641	Phenotype	The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.	Phenotypes
D002874	Chromosome Mapping	Any method used for determining the location of and relative distances between genes on a chromosome.	Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D001215	Asparaginase	A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.	Asparaginase II,Asparaginase medac,Asparagine Deaminase,Colaspase,Crasnitin,Elspar,Erwinase,Kidrolase,Leunase,Paronal,Deaminase, Asparagine,medac, Asparaginase
D001233	Aspergillus nidulans	A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.	Aspergillus nidulellus,Emericella nidulans