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Antiserum sheep 3 against rat brain glutamate decarboxylase (GAD) was employed for the immunohistochemical localization of GAD-immunoreactive nerve terminals in the substantia nigra (SN). To test whether the antiserum specifically localized GAD-containing axon terminals, the effect of kainic acid-induced striatal lesions on the reactive nerve endings in the SN was investigated. Seven days after the injection of 1 microgram kainic acid into the striatum, a 65% decrease in GAD-enzyme activity occurred in the ipsilateral SN. On immunohistochemical examination there was correspondingly a marked reduction of GAD-positive terminals. The parallel decrease in biochemical and immunohistochemical GAD activity indicates that antiserum sheep 3 can be used as a specific immunohistochemical probed for GAD-containing elements.
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
April 1977,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
March 1998,
Neuroscience letters,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
September 1993,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
September 2000,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
October 1977,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
June 1981,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
February 1996,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
November 1976,
Brain research,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
January 1985,
Journal de physiologie,
W H Oertel, and
D E Schmechel, and
M J Brownstein, and
M L Tappaz, and
D H Ransom, and
I J Kopin
June 1980,
Brain research,
