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We examined the changes in ingestive behavior, serum glucose (Glc) and free fatty acids (FFA) concentrations in male rats following intracerebroventricular (i.c.v.) injection of spermine (SPM). In satiated rats, over a 53.3 nmol of SPM suppressed feeding and drinking behavior in a dose-dependent manner. The median suppressive dose was 90.8 nmol for feeding behavior and 68.3 nmol for drinking behavior. Spermidine also suppressed ingestive behavior but the potency was appreciable weak compared to that of SPM, and the occurrence of the maximal suppression was observed 2-3 days later than that of SPM. The most significant anorexia and adipsia induced by SPM appeared between 16 and 36 hr after i.c.v. administration. SPM (180 nmol) produced a biphasic increase in serum Glc concentration. The 1st peak was at 1 hr and the other peak was 24 hr after the dosing. The same dose of SPM elevated serum FFA concentrations gradually, and the maximal increase appeared 24 hr after the injection. As less than a 120 nmol dose of SPM did not alter serum Glc and FFA concentrations, there seems to be no causal relation between SPM-induced anorexia, and changes in serum Glc and FFA concentrations. Nevertheless, the findings that a very small dose of SPM produced anorexia and adipsia support the possibility that SPM may play some functional role in the brain.
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
April 1982,
The American journal of physiology,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
January 1968,
Israel journal of medical sciences,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
December 1984,
Life sciences,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
September 1977,
The American journal of physiology,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
August 1982,
Japanese journal of pharmacology,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
April 1998,
Alcoholism, clinical and experimental research,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
January 2011,
The Journal of toxicological sciences,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
December 1992,
Behavioral neuroscience,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
September 1968,
Zeitschrift fur klinische Chemie und klinische Biochemie,
H Kohno, and
T Sakurada, and
T Suzuki, and
K Kisara, and
H Satoh
January 1968,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
