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A single intramuscular dose of one gram of cefazoline was administered to fifty eight patients undergoing total hip replacement. The elimination of the antibiotic in femoral head is parallel to the blood elimination but ten times lower. Twelve hours after injection, levels of 0.5 microgram/g (i.e. higher than MIC of Staphylococcus aureus normally isolated from post surgery infections) are still detected in capsule and femoral head.
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