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1. Hydrolysis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA-peptide) has been measured in soluble and particulate fractions of human small intestinal mucosa. 2. Both soluble and particulate fractions contained enzymic activity capable of splitting the PABA-peptide. In the particulate fractions this activity increased threefold towards the distal small intestine. 3. Neither soluble nor particulate activity was inhibited by the chymotrypsin inhibitor 1-chloro-4-phenyl-3-L-toluene-p-sulphonamidobutan-2-one (TPCK). 4. Column chromatography on Sephacryl S-300 resolved a peak of PABA-peptide hydrolase activity that was clearly distinct from other known brush-border peptide hydrolases and from added chymotrypsin standard. 5. This PABA-peptide hydrolase thus represents a distinct intestinal enzyme, possibly bound to the brush-border membrane, which could account for the residual urinary PABA recovery observed in patients and animal models with exocrine pancreatic insufficiency.
E E Sterchi, and
J R Green, and
M J Lentze
February 1981,
European journal of pediatrics,
E E Sterchi, and
J R Green, and
M J Lentze
March 1985,
Annales de pediatrie,
E E Sterchi, and
J R Green, and
M J Lentze
December 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
E E Sterchi, and
J R Green, and
M J Lentze
August 1978,
The Journal of pharmacology and experimental therapeutics,
E E Sterchi, and
J R Green, and
M J Lentze
January 1981,
Quarterly journal of experimental physiology (Cambridge, England),
E E Sterchi, and
J R Green, and
M J Lentze
March 1979,
Zeitschrift fur Gastroenterologie,
E E Sterchi, and
J R Green, and
M J Lentze
October 1979,
Biochemical medicine,
E E Sterchi, and
J R Green, and
M J Lentze
May 1978,
The Journal of pediatrics,
E E Sterchi, and
J R Green, and
M J Lentze
June 1983,
Hepato-gastroenterology,
E E Sterchi, and
J R Green, and
M J Lentze
September 1976,
Deutsche medizinische Wochenschrift (1946),
