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The in vitro effect of a calf thymus extract, thymostimulin (TP--1), on the E-rosette-forming capacity and on the PHA blastogenic response of peripheral blood lymphocytes was evaluated in 20 patients with untreated Hodgkin's disease. The mean percentage of lymphocytes forming E rosettes increased in patients from 44.2% to 57.5% (P less than 0.005). The mean PHA stimulation index rose with all three concentrations tested, but returned to the normal range only with the highest PHA concentration (60 mu/ml). An increase in the immune parameters was greatest in those patients who presented with decreased E-rosetting cells of total lymphocyte counts or whose disease was Stage III or IV or of mixed cellular histology.
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A Velardi, and
P Rambotti, and
C Cernetti, and
A M Bracaglia, and
E Ballatori, and
S Davis
January 1975,
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M F Martelli, and
A Velardi, and
P Rambotti, and
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Przeglad lekarski,
M F Martelli, and
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M F Martelli, and
A Velardi, and
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A M Bracaglia, and
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M F Martelli, and
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M F Martelli, and
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June 1987,
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M F Martelli, and
A Velardi, and
P Rambotti, and
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A M Bracaglia, and
E Ballatori, and
S Davis
August 1967,
Annals of internal medicine,
M F Martelli, and
A Velardi, and
P Rambotti, and
C Cernetti, and
A M Bracaglia, and
E Ballatori, and
S Davis
July 1999,
The Journal of veterinary medical science,
