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Cell-mediated hypersensitivity (CMH) to house dust mite antigens, as determined by increased DNA synthesis after coculture of mononuclear cells with Dermatophagoides farinae extract, was demonstrated in 11 of 16 children with atopic dermatitis (AD) as compared with two of 14 control subjects. Patient and control responses peaked at the same antigen dose (12.4 micrograms of mite protein per 10(5) cells). Patient responses were significantly greater at all mite protein concentrations. The increased DNA synthesis of stimulated cells was demonstrated to be a T-cell response in the one patient in whom T-cell-enriched cultures were studied. There was no relationship between CMH and lgE-mediated hypersensitivity to D farinae in the patient group. It is suggested that AD is associated with CMH reactions to allergens and that antigen competition may be involved in the reduced CMH responses to mitogens and antigens noted by other investigators.
W L Elliston, and
E A Heise, and
C C Huntley
January 1999,
Pediatric dermatology,
W L Elliston, and
E A Heise, and
C C Huntley
December 1986,
Journal of the American Academy of Dermatology,
W L Elliston, and
E A Heise, and
C C Huntley
February 2006,
Contact dermatitis,
W L Elliston, and
E A Heise, and
C C Huntley
November 1999,
Clinical and experimental dermatology,
W L Elliston, and
E A Heise, and
C C Huntley
January 1991,
Acta dermato-venereologica,
W L Elliston, and
E A Heise, and
C C Huntley
March 1983,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
W L Elliston, and
E A Heise, and
C C Huntley
January 1980,
Przeglad dermatologiczny,
W L Elliston, and
E A Heise, and
C C Huntley
September 1997,
Arhiv za higijenu rada i toksikologiju,
W L Elliston, and
E A Heise, and
C C Huntley
November 1994,
Archives of dermatology,
W L Elliston, and
E A Heise, and
C C Huntley
December 2012,
Acta clinica Croatica,
