Biomaterial Database

Oral theophylline disposition in cystic fibrosis. 1982

J W Georgitis, and H Eigen, and R Warner, and M A Gonzales

Theophylline absorption and disposition of CF patients have not been systematically studied. To evaluate these factors in CF subjects, seven CF patients were fasted overnight and administered a dose of aminophylline liquid equivalent to 4 mg/kg of anhydrous theophylline. Liver function tests (SGOT, GGT, alkaline phosphatase) were normal in all seven patients. maximum serum theophylline concentrations occurred between 30 and 60 minutes post-dose in all subjects and ranged from 4.8 to 8.6 mcg/ml. These values are similar to those reported in non-CF subjects for a single 4 mg/kg oral dose. The mean serum half-life of 3.5 hours with a range of 1.2 to 5.0 hours is similar to that reported in non-CF populations. The authors conclude that theophylline elimination (half-lives) in CF patients with normal liver function is similar to those of normal and asthmatic patients. CF patients with clinical liver disease may have a decreased clearance and should be carefully monitored.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008111	Liver Function Tests	Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.	Function Test, Liver,Function Tests, Liver,Liver Function Test,Test, Liver Function,Tests, Liver Function
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003550	Cystic Fibrosis	An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.	Mucoviscidosis,Cystic Fibrosis of Pancreas,Fibrocystic Disease of Pancreas,Pancreatic Cystic Fibrosis,Pulmonary Cystic Fibrosis,Cystic Fibrosis, Pancreatic,Cystic Fibrosis, Pulmonary,Fibrosis, Cystic,Pancreas Fibrocystic Disease,Pancreas Fibrocystic Diseases
D005260	Female		Females
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations