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The effect of chronic oral contraceptive (OC) usage on the disposition of theophylline was examined. Aminophylline solution (4 mg/kg) was given orally to 8 healthy female non-OC users and to 8 healthy women who were chronic (greater than 6 months) OC users. The OC user group had a significantly lower total plasma clearance of theophylline than women not using OC (35.1 +/- 5.6 vs. 53.1 +/- 14.5 ml/h/kg). The t1/2 was also significantly prolonged in the OC group (9.79 +/- 1.43 vs. 7.34 +/- 1.75 h) while the volume of distribution was similar between the 2 groups. The serum ethinylestradiol (EE) concentrations after oral OC administration were measured simultaneously. The apparent clearance of EE was about 30% lower in the OC users. A significant positive correlation was found between the apparent clearance of EE and the plasma clearance of theophylline. The effects of OC are predominantly due to chronic use with decreased elimination of both theophylline and EE.
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
June 1983,
The Journal of laboratory and clinical medicine,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
June 1984,
Clinical pharmacology and therapeutics,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
May 1976,
Clinical pharmacology and therapeutics,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
July 1978,
The Journal of allergy and clinical immunology,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
January 1984,
Therapeutic drug monitoring,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
July 1990,
British journal of clinical pharmacology,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
July 1983,
Contraception,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
January 1984,
Obstetrics and gynecology,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
March 1982,
Annals of allergy,
K M Tornatore, and
R Kanarkowski, and
T L McCarthy, and
M J Gardner, and
A M Yurchak, and
W J Jusko
February 1977,
Obstetrics and gynecology,
