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Using [14C]leucine pulse label in vivo, the dynamics of transferrin synthesis and its intracellular transport in rat liver and the changes in the molecular sizes of the newly formed transferrin chains during this transport were investigated. The transferrin radioactivity peaks in the rough and smooth endoplasmic reticulum and in Golgi vesicles were observed on the 15th, 20th and 20-30th min after injection of the pulse label. In blood stream the [14C]transferrin was detected 30 min after the label administration, the maximum of radioactivity being observed on the 60th min. The intracellular transport of transferrin was accompanied by changes in its molecular weight. The molecular weights of the transferrin precursors from the rough and smooth endoplasmic reticulum, of immunoreactive transferrin from Golgi vesicles and of circulating transferrin are 86 000-88 000, 84 000 and 77 000, respectively. These variations in molecular weights are indicative of a complex reaction sequence of posttranslational maturation of transferrin in the liver, which includes in all probability proteolysis and glycosylation.
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
April 1982,
The Journal of biological chemistry,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
September 1972,
The Journal of biological chemistry,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
August 1974,
Biochimica et biophysica acta,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
May 1969,
Comparative biochemistry and physiology,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
January 1988,
Progress in clinical and biological research,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
September 1977,
FEBS letters,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
July 1971,
The British journal of nutrition,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
March 1988,
Biochimica et biophysica acta,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
June 1976,
Biochimica et biophysica acta,
V S Gaitskhoki, and
N A Timchenko, and
L T Timchenko, and
L V Puchkova, and
Kh A Aslanov
January 1973,
Voprosy meditsinskoi khimii,
