-transparent.png){kind=logo}
Central nervous system gamma-aminobutyric acid (GABA) activity was demonstrated to be an age- and sex-dependent phenomenon through the study of GABA concentration in lumbar CSF obtained from 87 drug-free normal individuals. Evaluation of the data from homogeneous subgroups of this population disclosed that both the propensity of lumbar CSF GABA levels to decrease with age and the magnitude of the rostrocaudal GABA concentration gradient are more pronounced in females, suggesting possible neuroendocrine involvement. Thus, age and sex are important variables that normally influence central GABAergic activity. Patient populations included in clinical investigations must be age- and sex-matched to avoid invalid conclusions biased by these physiologic variations in CSF GABA concentrations.
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
January 1966,
Acta neurologica latinoamericana,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
September 1985,
Neuroscience letters,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
January 1963,
Therapie,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
October 1958,
Nature,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
January 1981,
Seikagaku. The Journal of Japanese Biochemical Society,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
January 1986,
Neirofiziologiia = Neurophysiology,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
March 1985,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
December 1974,
Proceedings of the National Academy of Sciences of the United States of America,
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
November 1961,
Deutsche medizinische Wochenschrift (1946),
T A Hare, and
J H Wood, and
B V Manyam, and
R H Gerner, and
J C Ballenger, and
R M Post
February 1962,
Zeitschrift fur arztliche Fortbildung,
