Biomaterial Database

Studies in man of partially absorbed dietary fats. 1978

S A Hashim, and V K Babayan

A saturated long-chain triglyceride (SLCT) has been prepared by esterification with glycerol of the saturated long-chain fatty acid fraction of coconut oil, isolated by molecular distillation of the hydrolyzed oil. The resultant SLCT is comprised principally of stearate (89%) and palmitate (11%). The intestinal absorption of SLCT in man was compared with that of corn oil or a 1:1 mixture of SLCT and corn oil. Each fat or the mixture was incorporated in isocaloric amounts into a complete formula diet deriving 30% of its caloric content from fat, 55% from carbohydrate (dextrose), and 15% from protein (casein). The formula diets were administered in sequential feeding periods as the sole source of food. The results indicate that SLCT was poorly absorbed (31 to 39%) compared with virtually complete absorption of corn oil (98%). Fat absorption was improved when the dietary fat was an equal mixture of SLCT and corn oil. The poor absorption of SLCT was ascribed to its high melting point and related to impaired emulsification and micellar solubilization in the small intestine.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D009821	Oils	Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
D003313	Zea mays	A plant species of the family POACEAE. It is a tall grass grown for its EDIBLE GRAIN, corn, used as food and animal FODDER.	Corn,Indian Corn,Maize,Teosinte,Zea,Corn, Indian
D004041	Dietary Fats	Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.	Fats, Dietary,Dietary Fat,Fat, Dietary
D005227	Fatty Acids	Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)	Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014280	Triglycerides	An ester formed from GLYCEROL and three fatty acid groups.	Triacylglycerol,Triacylglycerols,Triglyceride