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To further define developmental changes in bile acid metabolism, we determined the kinetics of taurocholate uptake by hepatocytes isolated from Sprague-Dawley rats at 7, 14, 21, 28, and 56 days of age. There was a progressive increase in taurocholate uptake with age. The uptake process exhibited saturable kinetics in every age group with a maximum uptake velocity attained above a taurocholate concentration of 200 microM. There were no differences in Km values but Vmax increased progressively between 7 and 56 days of age. These data suggest that the deficit in hepatic excretory function observed in immature mammals of several species may, in part, be related to decreased transport of bile acids.
F J Suchy, and
W F Balistreri
November 1979,
The Journal of pharmacology and experimental therapeutics,
F J Suchy, and
W F Balistreri
April 1987,
The American journal of physiology,
F J Suchy, and
W F Balistreri
January 1985,
Biology of the neonate,
F J Suchy, and
W F Balistreri
November 1986,
Carcinogenesis,
F J Suchy, and
W F Balistreri
November 1979,
Research communications in chemical pathology and pharmacology,
F J Suchy, and
W F Balistreri
January 1987,
Hepatology (Baltimore, Md.),
F J Suchy, and
W F Balistreri
June 1977,
Naunyn-Schmiedeberg's archives of pharmacology,
F J Suchy, and
W F Balistreri
December 1976,
European journal of biochemistry,
F J Suchy, and
W F Balistreri
December 1985,
Biochemical pharmacology,
F J Suchy, and
W F Balistreri
January 1993,
Pharmacology & toxicology,
