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An analytical procedure for the simultaneous determination of pethidine and norpethidine in plasma by selected ion monitoring is described. The method has a capacity of 15--20 analyses per hour and can be used to determine pethidine and norpethidine down to 25 ng ml(-1) and 5 ng ml(-1), respectively. The selected ion monitoring method has been compared with a method based on electron capture detection after analysis of pethidine and norpethidine in spiked plasma samples and in plasma from patients. The two methods are capable of performing selective and accurate determinations of pethidine and norpethidine, in the concentration ranges obtained in man after a single therapeutic dose of pethidine.
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
January 1977,
European journal of clinical pharmacology,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
May 1983,
Journal of chromatography,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
October 1983,
Journal of chromatography,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
January 1985,
Journal of chromatography,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
February 1981,
Analytical biochemistry,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
March 1987,
Journal of chromatography,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
October 1996,
Journal of chromatography. B, Biomedical applications,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
July 1977,
Journal of chromatography,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
January 1984,
Journal - Association of Official Analytical Chemists,
C Lindberg, and
M Berg, and
L O Boréus, and
P Hartvig, and
K E Karlsson, and
L Palmér, and
A M Thörnblad
May 1997,
Journal of chromatography. B, Biomedical sciences and applications,
