BIOMAT Database Logo BIOMAT Database Logo

Impairment of hepatic drug oxidation by propoxyphene. 1982

D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D011431 Dextropropoxyphene A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect. D-Propoxyphene,Darvon,Propoxyphene,Propoxyphene Hydrochloride,Propoxyphene Hydrochloride, (R*,R*)-(+-)-Isomer,Propoxyphene Hydrochloride, (R-(R*,R*))-Isomer,Propoxyphene Hydrochloride, (R-(R*,S*))-Isomer,Propoxyphene Hydrochloride, (S-(R*,R*))-Isomer,Propoxyphene Maleate, (+)-Isomer,Propoxyphene Phosphate, (S-(R*,S*))-Isomer,Propoxyphene Sulfate, (S-(R*,S*))-Isomer,D Propoxyphene,Hydrochloride, Propoxyphene
D004316 Doxepin A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors. Apo-Doxepin,Aponal,Deptran,Desidox,Doneurin,Doxepia,Doxepin Hydrochloride,Doxepin Hydrochloride, Cis-Trans Isomer Mixture (approximately 1:5),Doxepin beta,Doxepin-RPh,Espadox,Mareen,Novo-Doxepin,Prudoxin,Quitaxon,Sinequan,Sinquan,Xepin,Zonalon,Apo Doxepin,ApoDoxepin,Doxepin RPh,Hydrochloride, Doxepin,Novo Doxepin
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Impairment of hepatic drug metabolism by carbon tetrachloride inhalation.
January 1970, Toxicology and applied pharmacology,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Hepatic microsomes and drug oxidation.
June 1968, Science (New York, N.Y.),
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Acute inhibition of oxidative drug metabolism by propoxyphene (Darvon).
June 1979, Biochemical pharmacology,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Genetic factors in hepatic drug oxidation.
January 1976, Progress in liver diseases,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Modification of hepatic microsomal oxidative drug metabolism in rats by the opiate maintenance drugs acetylmethadol, propoxyphene, and methadone.
September 1979, Life sciences,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Drug interaction? Orphenadrine with propoxyphene.
May 1970, The New England journal of medicine,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Neonatal drug withdrawal from propoxyphene.
May 1976, JAMA,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
[Drug dependence on propoxyphene (Darvon)].
May 1976, L'union medicale du Canada,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Effects of nifedipine on hepatic drug oxidation.
January 1988, Pharmacology,
D R Abernethy, and D J Greenblatt, and K Steel, and R I Shader
Impairment of hepatic drug metabolism in alcoholics.
January 1979, British journal of clinical pharmacology,
Copied contents to your clipboard!