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On consecutive days sphincter pressure (pull-through-perfusion manometry) and gastrooesophageal reflux (continuous pH measurements) were determined under basal conditions and after application of pentagastrin (6 microgram/kg b.w.s.c.) in 44 patients. In the half of patients with reflux disturbances of sphincter pressure were not evident under basal conditions and under pentagastrin. In patients with lowered sphincter pressure reflux frequency was found to be higher and single reflux duration was found to be lower than in patients with normal or elevated sphincter pressure.
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