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Under basal conditions serum gastrin concentration was compared with lower oesophageal sphincter pressure (pull-through perfusion manometry) and gastrooesophageal reflux (continuous pH measurements) in 72 patients. Between patients with low, middle and high basal gastrin level no differences were obtained for mean sphincter pressure. Mean reflux frequency and total reflux duration were increased significantly in patients with high gastrin level compared with patients with low gastrin level. Mean basal gastrin level was found to be higher in patients with symptoms of reflux than in patients without symptoms.
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