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Three metabolites of mebendazole were isolated from the bile of rats dosed with a mixture of mebendazole and pentadeuteromebendazole. The identification was based upon the appearance of the characteristic doublet in the mass spectrum of the compounds and the comparison of their fragmentations with those of authentic compounds. Cochromatography of the metabolites with the authentic compounds on HPLC supported the identification. Methyl-5(6)-(alpha-hydroxybenzyl)-2-benzimidazole carbamate, 2-amino-5(6)-(alpha-hydroxybenzyl) benzimidazole and 2-amino-5(6)-benzoylbenzimidazole were identified as metabolites after enzymic conjugate hydrolysis. Some unmetabolized mebendazole was also found.
R J Allan, and
T R Watson
February 1979,
Xenobiotica; the fate of foreign compounds in biological systems,
R J Allan, and
T R Watson
June 1993,
Xenobiotica; the fate of foreign compounds in biological systems,
R J Allan, and
T R Watson
May 1977,
Chemical & pharmaceutical bulletin,
R J Allan, and
T R Watson
August 1995,
Xenobiotica; the fate of foreign compounds in biological systems,
R J Allan, and
T R Watson
June 1967,
The Journal of pharmacy and pharmacology,
R J Allan, and
T R Watson
July 1976,
Research communications in chemical pathology and pharmacology,
R J Allan, and
T R Watson
September 2000,
Journal of agricultural and food chemistry,
R J Allan, and
T R Watson
January 1992,
Drug metabolism and disposition: the biological fate of chemicals,
R J Allan, and
T R Watson
July 1983,
Archives of biochemistry and biophysics,
