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A glass capillary gas chromatographic-mass spectrometric method for the analysis of 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline in urine, plasma and blood platelets was developed. The method involves the use of a deuterated analogue as internal standard, addition of semicarbazide, extraction with methylene chloride and formation of pentafluoropropionyl derivatives. The 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline was found to occur in the urine of controls and alcoholics as both the free and conjugated compound. In the controls the mean level of free and conjugated 60MTHBC was 75 +/- 20 nmole/l. When intoxicated, the alcoholics had a statistically higher excretion rate of the conjugate(s) than the controls. The compound was not detectable in blood platelets or plasma.
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
March 1994,
Journal of pharmaceutical sciences,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
January 1981,
Biochemical pharmacology,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
May 1983,
Biochemical pharmacology,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
January 1992,
Journal of medicinal chemistry,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
May 1984,
Acta pharmacologica et toxicologica,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
June 1990,
Journal of chromatography,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
October 1997,
Planta medica,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
December 1995,
Pharmacology, biochemistry, and behavior,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
April 1981,
Food and cosmetics toxicology,
O Beck, and
T R Bosin, and
A Lundman, and
S Borg
September 1999,
Arzneimittel-Forschung,
