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A comparison of two analytical methods of quinidine plasma determination--the modified extraction fluorometric method and the mass spectrometric method--was made. Plasma supplies collected at steady state from normal human volunteers participating in a bioavailability study were analyzed, using both methods. A total of 359 samples were analyzed. Comparison of both sets of values, by linear regression, yielded an r2 value of 0.84. The results of this comparison were consistent with the results reported by others, confirming that the commonly used extraction fluorometric method of quinidine determination is sufficiently accurate for monitoring quinidine plasma concentrations in the patient care setting, as well as for bioavailability comparisons between products.
G H Smith, and
R H Levy
June 1976,
Clinical chemistry,
G H Smith, and
R H Levy
January 1982,
Clinical chemistry,
G H Smith, and
R H Levy
April 1973,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
G H Smith, and
R H Levy
May 2016,
Biomedical chromatography : BMC,
G H Smith, and
R H Levy
March 1986,
Clinical chemistry,
G H Smith, and
R H Levy
January 1981,
Journal of clinical pharmacology,
G H Smith, and
R H Levy
January 2000,
Rapid communications in mass spectrometry : RCM,
G H Smith, and
R H Levy
June 1980,
Journal of pharmaceutical sciences,
G H Smith, and
R H Levy
January 2003,
Journal of chromatography. A,
G H Smith, and
R H Levy
November 1978,
Clinical chemistry,
