[Cytochemical study of peroxidase activity and the peroxidase-endogenous hydrogen peroxide system in the peripheral blood neutrophils of mice exposed to prodigiozan and retabolil]. 1982

Iu V Golikov, and V A Lomonosov, and L P Danilova, and I I Govberg, and V V Rogovin

The paper concerns changes in the activity of some enzymes of azurophil granules of mouse neutrophils under a single administration of the bacterial polysaccharide prodigiosan and the synthetic anabolic hormone retabolil. Prodigiosan increases 1.4-fold the activity of the peroxidase-hydrogen peroxide system in azurophil granules of intact mice. In mice with leukopenia, prodigiosan normalizes the leukocyte count after 24 hours. At the same time there is an increase in the activity of peroxidase. It is assumed that under the effect of the same drug the cells of the animals in different physiological conditions may show an activation of the different components of antimicrobial defence. Retabolil raises the activity of peroxidase 96 hours after the first administration. Following 192 hours the activity reduces to normal and remains unchanged after the second drug administration.

UI MeSH Term Description Entries
D008297 Male Males
D009277 Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position. 19-Nortestosterone,Estrenolone,Norandrostenolone,Nortestosterone,17-Hydroxy-Estr-4-Ene-3-One,17beta-Hydroxy-19-Nor-4-Androsten-3-One,17beta Hydroxy 19 Nor 4 Androsten 3 One
D009504 Neutrophils Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D010544 Peroxidases Ovoperoxidase
D011135 Polysaccharides, Bacterial Polysaccharides found in bacteria and in capsules thereof. Bacterial Polysaccharides
D011354 Prodigiozan A polysaccharide extracted from Serratia marcescens and other bacteria. It activates enzymatic activity of macrophages and stimulates phagocytic processes. Prodigiosan
D006651 Histocytochemistry Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods. Cytochemistry
D006861 Hydrogen Peroxide A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D000077603 Nandrolone Decanoate Decanoic acid ester of nandrolone that is used as an anabolic agent to prevent or treat WASTING SYNDROME associated with severe chronic illness or HIV infection (HIV WASTING SYNDROME). It may also be used in the treatment of POSTMENOPAUSAL OSTEOPOROSIS. 17 beta-Hydroxyestr-4-en-3-one 17-decanoate,19-Nortestosterone Decanoate,19-nor-4-Androstene-17 beta-ol-3-one 17-decanoate,Decadurabolin,Decadurobolin,Retabolil,Retabolyl,17 beta Hydroxyestr 4 en 3 one 17 decanoate,19 Nortestosterone Decanoate,19 nor 4 Androstene 17 beta ol 3 one 17 decanoate
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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