-transparent.png){kind=logo}
4,4'-Diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) inhibits the typical development of protrusions, regularly seen after treatment of isolated hepatocytes with phalloidin. The degree of inhibition depends on the time of preincubation and on the concentration of DIDS, but not on the concentration of phalloidin. DIDS is more effective than H2DIDS. The inhibition by both compounds is irreversible. The binding capacity of hepatocytes for H2DIDS is much higher than that of the phalloidin-insensitive hepatoma cells. Gel electrophoresis of lysates from cells, pretreated with 3H2DIDS demonstrates that actin binds very little of the inhibitor. Our results suggest that a protein structure on the surface of hepatocytes, needed for the response to phalloidin, is influenced by DIDS or H2DIDS.
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
December 1991,
Biochemical pharmacology,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
November 1986,
Biochemical and biophysical research communications,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
November 1982,
Plant physiology,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
May 1984,
Biochemical and biophysical research communications,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
January 1986,
The Journal of membrane biology,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
April 1994,
European journal of pharmacology,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
March 1988,
European journal of pharmacology,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
May 1977,
The Journal of membrane biology,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
December 2003,
Journal of pharmacological sciences,
E Petzinger, and
E Grundmann, and
L B Veil, and
M Frimmer, and
H Fasold
October 1976,
The Journal of membrane biology,
