-transparent.png){kind=logo}
In an effort to understand the mechanism of action of parathyroid hormone (PTH) on the myocardium, we examined the effect of PTH on the function of isolated heart mitochondria. The hormone inhibited mitochondrial respiration in the presence of malate or beta-hydroxybutyrate but not succinate as substrates. It also inhibited phosphorylation and uncoupled oxidative phosphorylation. These effects of PTH were dose dependent and occurred only in the presence of calcium. A change in calcium concentration from zero to 2 mM did not affect mitochondrial function. PTH also stimulated mitochondrial ATPase. The inhibitory effect of PTH on mitochondrial respiration and on oxidative phosphorylation would result in decreased ATP synthesis and, hence, reduced availability of ATP. Such a sequence of events may provide an explanation for a potential long-term adverse effect of the hormone on the myocardium.
E Bogin, and
J Levi, and
I Harary, and
S G Massry
January 1965,
Vestnik Leningradskogo universiteta. Seriia biologii,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
July 1954,
Biochimica et biophysica acta,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
November 1953,
The Journal of biological chemistry,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
March 1966,
Comparative biochemistry and physiology,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
January 1966,
Federation proceedings. Translation supplement; selected translations from medical-related science,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
May 1965,
Biochemical and biophysical research communications,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
January 1993,
The British journal of nutrition,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
July 1972,
The American journal of physiology,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
January 1962,
Archives of biochemistry and biophysics,
E Bogin, and
J Levi, and
I Harary, and
S G Massry
February 1985,
The Biochemical journal,
