Biomaterial Database

Treatment of keloid scars by combined cryosurgery and intralesional corticosteroids. 1982

B Hirshowitz, and D Lerner, and A R Moscona

Fifty-eight patients with keloid scars were subjected to combined cryosurgery and intralesional corticosteroid therapy. Complete regression of the scars occurred in 41 patients. In 8 patients the scars improved, and there was no improvement in 9 patients. Keloid scars of the earlobes were the most responsive to treatment. The possibility of differing biological activity of cryosurgery and corticosteroids complementing each other is postulated, and a combination of their respective actions may offer promise in treatment.

UI	MeSH Term	Description	Entries
D007627	Keloid	A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.	Keloids
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D003452	Cryosurgery	The use of freezing as a special surgical technique to destroy or excise tissue.	Cryoablation,Cryoablations,Cryosurgeries
D004431	Ear, External	The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.	External Ear,Outer Ear,Ear, Outer,Ears, External,Ears, Outer,External Ears,Outer Ears
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D014221	Triamcinolone	A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)	Aristocort,Volon