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The effect of graded oral doses of 16,16-dimethyl-prostaglandin E2 (PG E2) on basal acid secretion in healthy volunteers was tested over a time period of 6 h. In addition, studies were conducted to determine whether pretreatment with this methylated PG-analog could prevent the characteristic fall in human gastric potential difference (PD) associated with intragastric instillation of 50 ml of 4 mmol/l Na-taurocholate. Basal acid output was reduced by 80--90% after 0.5 microgram/kg b.w. 16,16-dimethyl-PG E2. Half maximum inhibition was achieved by 0.1 microgram/kg b.w., whereas a 10 fold lower dose of 16,16-dimethyl-PG E2 (0.01 microgram/kg b.w.) effectively protected human gastric mucosa against the injurious effects of Na-taurocholate. In analogy to findings in animals it is, therefore, concluded that 16,16-dimethyl-PG E2 has two distinct properties in human stomach, antisecretory and protective ones, which were independent of each other.
H G Dammann, and
P Müller, and
H Kather, and
B Simon
January 1981,
Deutsche medizinische Wochenschrift (1946),
H G Dammann, and
P Müller, and
H Kather, and
B Simon
January 1992,
Journal of clinical gastroenterology,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
January 1994,
Archives internationales de pharmacodynamie et de therapie,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
June 1975,
Gastroenterology,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
December 1983,
Digestive diseases and sciences,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
January 1992,
Journal of clinical gastroenterology,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
March 1997,
Digestive diseases and sciences,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
February 1981,
Prostaglandins and medicine,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
October 1978,
Canadian journal of physiology and pharmacology,
H G Dammann, and
P Müller, and
H Kather, and
B Simon
December 1981,
The American journal of physiology,
