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Intraperitoneal inoculation of allogeneic lymphoid cells rapidly activates cytotoxic cells in the peritoneum which are nonadherent and express the NK-1, asialo-GM1, and Thy-1 antigens. Allogeneic spleen cells were very efficient at activating these natural killer (NK) cells, while allogeneic thymocytes were much less effective. Heat-killed allogeneic cells or sonicates also could augment NK activity.--Incompatbility at H-2K, H-2T-A, or H-2D readily evoked NK cell activity, while H-2S- and H-2I-E/C-associated a disparities did not. Non-H-2 differences also stimulated NK activity and augmentation was particularly evident in the Mls-disparate combinations. Thus, the same alloantigens which efficiently activate T cells also activate NK cells.
E A Clark, and
R D Holly
January 1987,
Immunogenetics,
E A Clark, and
R D Holly
January 1981,
Progress in clinical and biological research,
E A Clark, and
R D Holly
January 2000,
Methods in molecular biology (Clifton, N.J.),
E A Clark, and
R D Holly
January 2019,
Frontiers in immunology,
E A Clark, and
R D Holly
August 1989,
Immunology and cell biology,
E A Clark, and
R D Holly
March 1989,
European journal of immunology,
E A Clark, and
R D Holly
January 1981,
Texas reports on biology and medicine,
E A Clark, and
R D Holly
August 1990,
Revista espanola de enfermedades digestivas,
E A Clark, and
R D Holly
January 1987,
Advances in experimental medicine and biology,
