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N,N'-Dimethylurea (DMU) at 4 g/kg i.p. protected against the normal rise in blood glucose associated with alloxan-induced diabetes when it was administered to mice at 30 min or 2 hr prior to the i.v. injection of 75 mg/kg of alloxan. Blood glucose measurements were made 72 h post alloxan. At 30 min after the above dose of DMU alone (no alloxan) there was a significant rise in blood glucose but at 2 h after DMU there was no significant difference between control and DMU-treated animals. These data indicate that the primary mode of protection by DMU does not involve a rise in blood glucose. The data however are consistent with another mode of protection by DMU such as its scavenging of the hydroxyl radical, a cytotoxic species which can be generated from alloxan through a series of reactions.
R E Heikkila, and
E S Cabbat
October 1985,
Biochemical pharmacology,
R E Heikkila, and
E S Cabbat
March 1994,
Japanese journal of pharmacology,
R E Heikkila, and
E S Cabbat
January 1995,
Experientia,
R E Heikkila, and
E S Cabbat
February 1983,
Life sciences,
R E Heikkila, and
E S Cabbat
March 1947,
The Anatomical record,
R E Heikkila, and
E S Cabbat
September 2002,
European journal of pharmacology,
R E Heikkila, and
E S Cabbat
May 2016,
Journal of biochemical and molecular toxicology,
R E Heikkila, and
E S Cabbat
May 1976,
Biochemical pharmacology,
R E Heikkila, and
E S Cabbat
May 1962,
Archives of pathology,
R E Heikkila, and
E S Cabbat
November 1954,
Science (New York, N.Y.),
