BIOMAT Database Logo BIOMAT Database Logo

Alloxan-induced diabetes-evidence for hydroxyl radical as a cytotoxic intermediate. 1976

R E Heikkila, and B Winston, and G Cohen

UI MeSH Term Description Entries
D007515 Islets of Langerhans Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN. Islands of Langerhans,Islet Cells,Nesidioblasts,Pancreas, Endocrine,Pancreatic Islets,Cell, Islet,Cells, Islet,Endocrine Pancreas,Islet Cell,Islet, Pancreatic,Islets, Pancreatic,Langerhans Islands,Langerhans Islets,Nesidioblast,Pancreatic Islet
D008297 Male Males
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000432 Methanol A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness. Alcohol, Methyl,Carbinol,Sodium Methoxide,Wood Alcohol,Alcohol, Wood,Methoxide, Sodium,Methyl Alcohol
D000433 1-Propanol A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate. Alcohol, Propyl,Propanol,n-Propanol,Propyl Alcohol
D000440 Butanols Isomeric forms and derivatives of butanol (C4H9OH). Alcohols, Butyl,Butanol,Butylhydroxides,Hydroxybutanes,Butyl Alcohols
D000496 Alloxan Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

R E Heikkila, and B Winston, and G Cohen
Protection against alloxan-induced diabetes in mice by the hydroxyl radical scavenger dimethylurea.
November 1978, European journal of pharmacology,
R E Heikkila, and B Winston, and G Cohen
Alloxan-induced DNA strand breaks in pancreatic islets. Evidence for H2O2 as an intermediate.
February 1991, The Journal of biological chemistry,
R E Heikkila, and B Winston, and G Cohen
Pulse radiolytic investigations of the redox system alloxan-dialuric acid: evidence for a radical intermediate.
December 1979, Biochemical and biophysical research communications,
R E Heikkila, and B Winston, and G Cohen
Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis.
June 1984, The American journal of pathology,
R E Heikkila, and B Winston, and G Cohen
Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria.
October 1988, Kidney international,
R E Heikkila, and B Winston, and G Cohen
[Studies on biological damage by active oxygen. I. Protective effect of various hydroxyl radical scavengers against alloxan-induced diabetes].
November 1986, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
R E Heikkila, and B Winston, and G Cohen
Protection against alloxan-induced diabetes by various urea derivatives: relationship between protective effects and reactivity with the hydroxyl radical.
November 1979, The Journal of pharmacology and experimental therapeutics,
R E Heikkila, and B Winston, and G Cohen
Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure.
September 1988, The American journal of physiology,
R E Heikkila, and B Winston, and G Cohen
Observational evidence for interhemispheric hydroxyl-radical parity.
September 2014, Nature,
R E Heikkila, and B Winston, and G Cohen
6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate.
August 1973, Science (New York, N.Y.),
Copied contents to your clipboard!