Biomaterial Database

[The effect of 1 alpha-OH-D3 on the process of fracture healing (author's transl)]. 1980

J Tanaka

The purpose of this paper is to clarify the effect of 1 alpha-OH-D3 on the bone metabolism through fracture healing. Rats were fractured on the middle of femur and were given 1 alpha-OH-D3 every day. The relationship between biochemical and histological changes were studied through the process of fracture healing associated with remarkable remodeling. The results are summarized as follows: 1. As soon as serum Ca levels decreased temporarily after fracture, a increase of serum iP.T.H. levels occurred with the histological change such as a bone resorption. The secretion of P.T.H. is probably suppressed by 1 alpha-OH-D3 with subsequent increase of the resorption of bone tissue. 2. Following the increase of serum Ca levels, the decrease of serum iP.T.H. levels were observed, accompanied by the histological changes of bone formation. These changes were seen earlier in the 1 alpha-OH-D3 group than in the controlled group. 3. Bone formation in the 1 alpha-OH-D3 group could be seen at the same area at which the bone resorption had occurred before. 1 alpha-OH-D3 could promote osteocytic, osteoclastic osteolysis and also bone formation, activating basic multicellular units (B.M.U.). 4. Some difference was found in the uniting callus formation between 1 alpha-OH-D3 group and the controlled group. 5. In conclusion, administration of 1 alpha-OH-D3 during fracture healing is useful in stimulating direct callus formation from cortex.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010011	Osteocytes	Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.	Osteocyte
D010281	Parathyroid Hormone	A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.	Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D005264	Femoral Fractures	Fractures of the femur.	Femoral Fracture,Fracture, Femoral,Fractures, Femoral
D005594	Fracture Fixation, Intramedullary	The use of nails that are inserted into bone cavities in order to keep fractured bones together.	Intramedullary Nailing,Nailing, Intramedullary,Osteosynthesis, Fracture, Intramedullary,Fixation, Intramedullary Fracture,Fixations, Intramedullary Fracture,Fracture Fixations, Intramedullary,Intramedullary Fracture Fixation,Intramedullary Fracture Fixations,Intramedullary Nailings,Nailings, Intramedullary
D006887	Hydroxycholecalciferols	Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.	Hydroxyvitamins D,Hydroxycholecalciferol
D000469	Alkaline Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings