Biomaterial Database

[The dynamics of the drug release from suppositories. Part 5: Liberation of chlorpromazine from suppository bases (author's transl)]. 1981

J Pasich, and B Drobnicka, and A Kasprzyk

The authors determined the liberation of chlorpromazine hydrochloride from suppositories prepared with the polyethylene glycols PEG 1000, 1500, 2000, 4000, 6000 and their mixtures as well as with the lipophil bases cocoa butter, Witepsol W35 and Witepsol H15. The determinations were made with the apparatus described by Kerckhoffs and Huinziga using a phosphate buffer (pH = 7.4). It was found that the liberation was most rapid from hydrophilic polyethylene glycol bases; and the release rates decreased in the following order: PGE 4000 (75%) + PEG (25%) leads to PEG 4000 (75%) + glycerol (25%) leads to PEG 2000 leads to PEG 1500 (70%( + PEG 6000 (30%) leads to PEG 4000 leads to PEG 6000. The release from lipophil bases was poor.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D002746	Chlorpromazine	The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.	Aminazine,Chlorazine,Chlordelazine,Chlorpromazine Hydrochloride,Contomin,Fenactil,Largactil,Propaphenin,Thorazine,Hydrochloride, Chlorpromazine
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D013488	Suppositories	Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.	Rectal Suppositories,Vaginal Suppositories,Vaginal Suppository,Suppositories, Rectal,Suppositories, Vaginal,Suppository, Vaginal
D014677	Pharmaceutical Vehicles	A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)	Pharmaceutical Vehicle,Vehicle, Pharmaceutical,Vehicles, Pharmaceutical