Biomaterial Database

Changes in relative levels of linoleate to arachidonate in erythrocyte phosphatidylcholine in rats fed ethanol and arachidonate. 1981

G A Rao, and S C Goheen, and E C Larkin

Young male Sprague--Dawley rats were fed ad lib. for 4 weeks a liquid diet containing 34% of the calories as ethanol and 35% as fat (25 wt % linoleate). The ratio of the levels of linoleic acid to arachidonic acid (18:2/20:4) in erythrocyte phosphatidylcholine (PC) from alcohol-fed rats was greater than that from rats fed an isocaloric control diet. The increased 18:2/20:4 ratio in tissue lipids of animals ingesting ethanol is thought to be due to the reduced production of arachidonate from linoleate. In the present study we tested whether dietary arachidonate would mask the effects of alcohol on the 18:2/20:4 ratio in erythrocyte PC. Analysis of the fatty acid composition of erythrocyte PC of rats fed a diet supplemented with arachidonate showed that ethanol feeding did not alter the 18:2/20:4 ratio.

UI	MeSH Term	Description	Entries
D008041	Linoleic Acids	Eighteen-carbon essential fatty acids that contain two double bonds.	Acids, Linoleic
D008297	Male		Males
D010713	Phosphatidylcholines	Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D000431	Ethanol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.	Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001095	Arachidonic Acids		Eicosatetraenoic Acids,Acids, Arachidonic,Acids, Eicosatetraenoic
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus