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500 mg of powdered ampicillin (AMP; activity 108%) and 325 mg of talampicillin chlorhydrate (TMP; equivalent to 200 mg ampicillin with an activity of 100%) were administered orally to two groups of 15 fasting patients selected at random. Blood samples were collected after 1/2, 1, 2, 4 and 6 h and urine samples after 1, 2, 4 and 6 h. The AMP concentrations were determined by the microbiologic method. All patients received food 1 h after the drugs administration. Urine samples wee taken daily for the bacteriologic examination. The maximum seric peak for TMP was 4.2 microgram/ml at 1/2 h and for AMP of 4.6 microgram/ml after 1 h. It was stated that TMP is absorbed more quickly than AMP and it was not affected by the presence of food. Nevertheless, no differences were observed in the results of the clinical study.
N Mallo, and
F Dalet
July 1976,
British medical journal,
N Mallo, and
F Dalet
April 1976,
The Practitioner,
N Mallo, and
F Dalet
October 1975,
The British journal of clinical practice,
N Mallo, and
F Dalet
August 1981,
The Practitioner,
N Mallo, and
F Dalet
July 1976,
British medical journal,
N Mallo, and
F Dalet
August 1976,
British medical journal,
N Mallo, and
F Dalet
August 1977,
Drug and therapeutics bulletin,
N Mallo, and
F Dalet
January 1974,
Chemotherapy,
N Mallo, and
F Dalet
July 1975,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
N Mallo, and
F Dalet
June 1976,
British medical journal,
